The contribution of serial and parallel micro-perfusion to spatial variability in pulmonary inter- and intra-acinar blood flow

Show simple item record Clark, AR en Burrowes, KS en Tawhai, Merryn en 2011-11-17T04:58:26Z en 2010 en
dc.identifier.citation Journal of Applied Physiology 108(5):1116-1126 2009 en
dc.identifier.issn 8750-7587 en
dc.identifier.uri en
dc.description.abstract This study presents a theoretical model of combined series and parallel perfusion in the human pulmonary acinus that maintains computational simplicity while capturing some important features of acinar structure. The model provides a transition between existing models of perfusion in the large pulmonary blood vessels and the pulmonary microcirculation. Arterioles and venules are represented as distinct elastic vessels that follow the branching structure of the acinar airways. These vessels are assumed to be joined at each generation by capillary sheets that cover the alveoli present at that generation, forming a “ladderlike” structure. Compared with a model structure in which capillary beds connect only the most distal blood vessels in the acinus, the model with combined serial and parallel perfusion provides greater capacity for increased blood flow in the lung via capillary recruitment when the blood pressure is elevated. Stratification of acinar perfusion emerges in the model, with red blood cell transit time significantly larger in the distal portion of the acinus compared with the proximal portion. This proximal-to-distal pattern of perfusion may act in concert with diffusional screening to optimize the potential for gas exchange. en
dc.language EN en
dc.publisher American Physiological Society en
dc.relation.ispartofseries Journal of Applied Physiology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri en
dc.subject pulmonary blood flow en
dc.subject modeling en
dc.subject flow heterogeneity en
dc.subject NORMAL HUMAN LUNG en
dc.subject DOG LUNG en
dc.subject ARTERIAL TREE en
dc.subject RAT LUNG en
dc.subject DISTENSIBILITY en
dc.subject MORPHOMETRY en
dc.subject EXERCISE en
dc.subject VESSELS en
dc.subject ELASTICITY en
dc.title The contribution of serial and parallel micro-perfusion to spatial variability in pulmonary inter- and intra-acinar blood flow en
dc.type Journal Article en
dc.identifier.doi 10.1152/japplphysiol.01177.2009 en
pubs.issue 5 en
pubs.begin-page 1116 en
pubs.volume 108 en
dc.rights.holder Copyright: 2010 the American Physiological Society en
dc.identifier.pmid 20110543 en
pubs.end-page 1126 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 96533 en Bioengineering Institute en ABI Associates en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 20110543 en

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