Species-specific pulmonary arterial asymetry determines species differences in regional pulmonary perfusion

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dc.contributor.author Burrowes, KS en
dc.contributor.author Hoffman, EA en
dc.contributor.author Tawhai, Merryn en
dc.date.accessioned 2011-11-17T05:01:59Z en
dc.date.issued 2009 en
dc.identifier.citation Annals of Biomedical Engineering 37(12):2497-2509 2009 en
dc.identifier.issn 0090-6964 en
dc.identifier.uri http://hdl.handle.net/2292/9179 en
dc.description.abstract The functional significance of differences in pulmonary vascular branching and diameter asymmetry between the human and quadruped lung has not previously been addressed. To evaluate the contribution of branching asymmetry to observable species differences in blood flow gradients, computed distributions of blood flow were compared in structure-based models of the human and ovine pulmonary arteries. The models were derived using a combination of computed tomography and a volume-filling algorithm. Pressure, flow, and deformed vessel diameter were calculated in both species models using equations representing conservation of mass and momentum, and a pressure– diameter relationship. The major difference between the human and ovine results was the presence of a large region of ‘‘zone 4’’ flow and higher mean flows in the central region of the ovine lung compared to that in the human. Heterogeneity in tissue perfusion and the contribution of gravity were similar in both species models; however, the gravitationally directed gradients of perfusion in the human and ovine models were different and each consistent with human and quadruped measurements, respectively. The results suggest that measured species differences in pulmonary perfusion gradients are largely determined by differences in branching asymmetry. en
dc.language EN en
dc.publisher Springer Verlag (Germany) en
dc.relation.ispartofseries Annals of Biomedical Engineering en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0090-6964/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Modeling en
dc.subject Pulmonary blood flow en
dc.subject Ovine en
dc.subject HUMAN LUNG en
dc.subject HETEROGENEITY en
dc.subject GRAVITY en
dc.subject VENTILATION en
dc.subject SUPINE en
dc.subject TREE en
dc.subject MORPHOMETRY en
dc.subject HUMANS en
dc.title Species-specific pulmonary arterial asymetry determines species differences in regional pulmonary perfusion en
dc.type Journal Article en
dc.identifier.doi 10.1007/s10439-009-9802-2 en
pubs.issue 12 en
pubs.begin-page 2497 en
pubs.volume 37 en
dc.rights.holder Copyright: 2009 Biomedical Engineering Society en
dc.identifier.pmid 19768544 en
pubs.end-page 2509 en
pubs.publication-status Published en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 96517 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 19768544 en

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