Abstract:
Occlusion of pulmonary arteries by autologous clot and bead emboli affect pulmonary function by elevating arterial pressures and reducing the number of functional gas exchange units in the lung. The occlusion of multiple arterioles at the acinar level can have a significant impact on pulmonary function. However, the contribution of acinar structure to perfusion distribution and the significance of arteriole occlusion is not well characterized.