The distribution of the growth factors FGF-2 and VEGF, and their receptors, in growing red deer antler

Show simple item record Lai, AK en Hou, Weilin en Verdon, Daniel en Nicholson, Louise en Barling, Peter en 2011-11-17T17:09:58Z en 2007 en
dc.identifier.citation Tissue & Cell 39(1):35-46 2007 en
dc.identifier.issn 0040-8166 en
dc.identifier.uri en
dc.description.abstract The cellular distributions of the growth factors FGF-2 and VEGF, and their receptors FGFR1, FGFR2 and FGFR3, and VEGFR-2 respectively, were visualized by immunohistochemistry and light microscopy in sections of growing red deer antler. Both of these signalling systems were widely expressed in the integument and osteocartilaginous compartments. FGF-2 was found in the same cells as all three FGFRs, indicating that FGF signalling may be principally autocrine. The patterns of labelling for VEGF and its receptor were similar to those seen for FGF-2 and FGFR-3, in both compartments. Our data are consistent with the findings of others in suggesting that FGF-2 induces expression of VEGF, to stimulate and maintain high rates of neovascularisation and angiogenesis, thereby providing nutrients to both velvet and bone as they rapidly grow and develop. The presence of FGF and VEGF and their receptors in epithelial cells suggests that these signalling systems play a role in skin development, raising the possibility that one or both may be involved in the close coupling of the coordinated growth of the integument and osteocartilage of antler, a process which is poorly understood at present. en
dc.language EN en
dc.publisher Elsevier Ltd. en
dc.relation.ispartofseries Tissue and Cell en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject FGF-2 en
dc.subject FGFR1 en
dc.subject FGFR2 en
dc.subject FGFR3 en
dc.subject VEGF en
dc.subject VEGFR-2 en
dc.subject antler en
dc.subject integument en
dc.subject epidermis en
dc.subject mesenchyme en
dc.subject chondrocyte en
dc.subject osteoblast en
dc.subject immunohistochemistry en
dc.subject BONE-GROWTH en
dc.subject FIBROBLAST en
dc.subject ANGIOGENESIS en
dc.subject SURVIVAL en
dc.subject MICE en
dc.subject INDUCTION en
dc.subject FGFR2 en
dc.subject SKIN en
dc.title The distribution of the growth factors FGF-2 and VEGF, and their receptors, in growing red deer antler en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.tice.2007.01.001 en
pubs.issue 1 en
pubs.begin-page 35 en
pubs.volume 39 en
dc.rights.holder Copyright: Elsevier Ltd. en
dc.identifier.pmid 17316726 en
pubs.end-page 46 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 71470 en Medical and Health Sciences en School of Medicine en Obstetrics and Gynaecology en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 17316726 en

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