A roadmap for drug discovery and its translation to small molecule agents in clinical development for tuberculosis treatment.

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dc.contributor.author Showalter, HD en
dc.contributor.author Denny, William en
dc.date.accessioned 2011-11-17T17:13:22Z en
dc.date.issued 2008 en
dc.identifier.citation Tuberculosis 88(Supplement 1):S3-S17 2008 en
dc.identifier.issn 1472-9792 en
dc.identifier.uri http://hdl.handle.net/2292/9213 en
dc.description.abstract Summary Drug discovery and development, from an initial disease treatment concept to a new drug application (NDA), is a complex, lengthy and expensive process. In this review we discuss the key stages of drug discovery and early development, including target identification and validation, assay development and screening, confirmed hits to leads, lead optimization, and progressing development candidates to an investigational new drug (IND) filing. We also provide particular examples of how this process is beginning to assist in the development of small molecule treatments for tuberculosis, by summarizing the status of the clinical development of several newer classes of drugs. These include the fluoroquinolones, oxazolidinones, diarylquinolines, and nitroimidazo-oxazoles and -oxazines. en
dc.language EN en
dc.publisher Elsevier Ltd. en
dc.relation.ispartofseries Tuberculosis en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1472-9792/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject tuberculosis en
dc.subject Mycobacterium tuberculosis en
dc.subject drug discovery en
dc.subject fluoroquinolones en
dc.subject oxazolidinones en
dc.subject diarylquinolines en
dc.subject nitroimidazooxazoles en
dc.subject nitroimidazooxazines en
dc.subject SUBSTANCE OFLOXACIN DL8280 en
dc.subject IN-VITRO ACTIVITIES en
dc.subject MYCOBACTERIUM-TUBERCULOSIS en
dc.subject DNA GYRASE en
dc.subject PULMONARY TUBERCULOSIS en
dc.subject ANTITUBERCULOSIS ACTIVITY en
dc.subject ANTIMICROBIAL AGENTS en
dc.subject MURINE TUBERCULOSIS en
dc.subject LEAD OPTIMIZATION en
dc.subject ATP SYNTHASE en
dc.title A roadmap for drug discovery and its translation to small molecule agents in clinical development for tuberculosis treatment. en
dc.type Journal Article en
dc.identifier.doi 10.1016/S1472-9792(08)70032-5 en
pubs.issue Supplement 1 en
pubs.begin-page S3 en
pubs.volume 88 en
dc.rights.holder Copyright: 2008 Elsevier Ltd. en
dc.identifier.pmid 18762151 en
pubs.end-page S17 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Review en
pubs.elements-id 79521 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Auckland Cancer Research en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2010-09-01 en
pubs.dimensions-id 18762151 en


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