Combined neutron and X-ray diffraction studies of DNA in crystals and solutions

Show simple item record Leal, RMF en Callow, S en Callow, P en Blakeley, MP en Cardin, CJ en Denny, William en Teixeira, SCM en Mitchell, EP en Forsyth, VT en 2011-11-17T17:16:00Z en 2010-11 en
dc.identifier.citation Acta Crystallographica Section D: Biological Crystallography 66(11):1244-1248 Nov 2010 en
dc.identifier.issn 0907-4449 en
dc.identifier.uri en
dc.description.abstract Recent developments in instrumentation and facilities for sample preparation have resulted in sharply increased interest in the application of neutron diffraction. Of particular interest are combined approaches in which neutron methods are used in parallel with X-ray techniques. Two distinct examples are given. The first is a single-crystal study of an A-DNA structure formed by the oligonucleotide d(AGGGGCCCCT)2, showing evidence of unusual base protonation that is not visible by X-ray crystallography. The second is a solution scattering study of the interaction of a bisacridine derivative with the human telomeric sequence d(AGGGTTAGGGTTAGGGTTAGGG) and illustrates the differing effects of NaCl and KCl on this interaction. en
dc.language EN en
dc.publisher international union of crystallography en
dc.relation.ispartofseries Acta Crystallographica Section D: Biological Crystallography en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from en
dc.rights.uri en
dc.subject neutron diffraction en
dc.subject X-ray diffraction en
dc.subject nucleic acids en
dc.subject DNA en
dc.subject acridine derivatives en
dc.subject deuteration en
dc.subject SAXS en
dc.subject SANS en
dc.subject A-DNA en
dc.subject DOUBLE HELIX en
dc.subject RESOLUTION en
dc.subject HYDRATION en
dc.subject PROGRAM en
dc.title Combined neutron and X-ray diffraction studies of DNA in crystals and solutions en
dc.type Journal Article en
dc.identifier.doi 10.1107/S0907444910017713 en
pubs.issue 11 en
pubs.begin-page 1244 en
pubs.volume 66 en
dc.rights.holder Copyright: International Union of Crystallography en
dc.identifier.pmid 21041945 en
pubs.end-page 1248 en
dc.rights.accessrights en
pubs.subtype Article en
pubs.elements-id 178190 en Medical and Health Sciences en Medical Sciences en Auckland Cancer Research en Science en Science Research en Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2011-11-17 en
pubs.dimensions-id 21041945 en

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