dc.contributor.author |
Ferguson, Lynnette |
en |
dc.contributor.author |
Denny, William |
en |
dc.date.accessioned |
2011-11-17T17:21:27Z |
en |
dc.date.issued |
2007 |
en |
dc.identifier.citation |
Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis 623(1-2):14-23 2007 |
en |
dc.identifier.issn |
0027-5107 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/9242 |
en |
dc.description.abstract |
This review provides an update on the mutagenicity of intercalating chemicals, as carried out over the last 17 years. The most extensively studied DNA intercalating agents are acridine and its derivatives, that bind reversibly but non-covalently to DNA. These are frameshift mutagens, especially in bacteria and bacteriophage, but do not otherwise show a wide range of mutagenic properties. Di-acridines or di-quinolines may be either mono- or bis-intercalators, depending upon the length of the alkyl chain separating the chromophores. Those which monointercalate appear as either weak frameshift mutagens in bacteria, or as non-mutagens. However, some of the bisintercalators act as “petite” mutagens in Saccharomyces cerevisiae, suggesting that they may be more likely to target mitochondrial as compared with nuclear DNA. Some of the new methodologies for detecting intercalation suggest this may be a property of a wider range of chemicals than previously recognised. For example, quite a number of flavonoids appear to intercalate into DNA. However, their mutagenic properties may be dominated by the fact that many of them are also able to inhibit topoisomerase II enzymes, and this property implies that they will be potent recombinogens and clastogens. DNA intercalation may serve to position other, chemically reactive molecules, in specific ways on the DNA, leading to a distinctive (and wider) range of mutagenic properties, and possible carcinogenic potential. |
en |
dc.language |
EN |
en |
dc.publisher |
Elsevier B.V. |
en |
dc.relation.ispartofseries |
Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from
18-May-2011 - Suggest an update for this record http://www.sherpa.ac.uk/romeo/issn/0027-5107/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
acridines |
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dc.subject |
DNA intercalation |
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dc.subject |
frameshift mutation |
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dc.subject |
"Petite" mutagenesis |
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dc.subject |
topoisomerase II inhibition |
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dc.subject |
covalent DNA binding |
en |
dc.subject |
HAMSTER V79 CELLS |
en |
dc.subject |
ADDUCT OPPOSITE DT |
en |
dc.subject |
FRAMESHIFT MUTAGENESIS |
en |
dc.subject |
ESCHERICHIA-COLI |
en |
dc.subject |
REVERSION ASSAY |
en |
dc.subject |
AFLATOXIN B-1 |
en |
dc.subject |
DROSOPHILA-MELANOGASTER |
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dc.subject |
SALMONELLA-TYPHIMURIUM |
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dc.subject |
SOLUTION CONFORMATION |
en |
dc.subject |
CLASTOGENIC ACTIVITY |
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dc.title |
Genotoxicity of non-covalent interactions: DNA intercalators |
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dc.type |
Journal Article |
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dc.identifier.doi |
10.1016/j.mrfmmm.2007.03.014 |
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pubs.issue |
1-2 |
en |
pubs.begin-page |
14 |
en |
pubs.volume |
623 |
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dc.rights.holder |
Copyright: ELSEVIER BV |
en |
dc.identifier.pmid |
17498749 |
en |
pubs.end-page |
23 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
72711 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Auckland Cancer Research |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2010-09-01 |
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pubs.dimensions-id |
17498749 |
en |