Inhibitors of phosphatidylinositol 3-kinases; the next wave of anti-cancer drugs?

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dc.contributor.author Rewcastle, Gordon en
dc.contributor.author Denny, William en
dc.date.accessioned 2011-11-17T17:22:47Z en
dc.date.issued 2009 en
dc.identifier.citation Chemistry in New Zealand 73(2):76-78 2009 en
dc.identifier.issn 0110-5566 en
dc.identifier.uri http://hdl.handle.net/2292/9249 en
dc.description.abstract Phosphatidylinositol 3-kinases (PI3Ks) are a family of lipid kinase enzymes, which catalyse the phosphorylation of the 3′-hydroxyl position of the inositol ring of phosphatidylinositol 4,5-diphosphate (PIP 2 ) to give the messenger molecule phosphatidylinositol 3,4,5-triphosphate (PIP 3 ) (Scheme 1). This then participates in a variety of physiological processes, including cell growth and differentiation. 1 The PI3Ks are divided into three classes (I-III) based on their structure, mode of regulation, and substrate specificity. ... en
dc.publisher New Zealand Institute of Chemistry en
dc.relation.ispartofseries Chemistry in New Zealand en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0110-5566/ http://www.sherpa.ac.uk/romeo/issn/0110-5566/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Inhibitors of phosphatidylinositol 3-kinases; the next wave of anti-cancer drugs? en
dc.type Journal Article en
pubs.issue 2 en
pubs.begin-page 76 en
pubs.volume 73 en
dc.rights.holder Copyright: New Zealand Institute of Chemistry en
pubs.author-url http://nzic.org.nz/CiNZ/articles/CiNZ_rewcastle.pdf en
pubs.end-page 78 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 88897 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Auckland Cancer Research en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2010-09-01 en


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