Synthesis and anti-inflammatory structure-activity relationships of thiazine-quinoline-quinones: inhibitors of the neutrophil respiratory burst in a model of acute gouty arthritis.

Chia, EW; Pearce, Allison; Berridge, MV; Larsen, L; Perry, NB; Sansom, CE; Godfrey, CA; Hanton, LR; Lu, Guo-Liang; Walton, M; Denny, William; Webb, VL; Copp, Brent; Harper, Jacquie

dc.contributor.author	Chia, EW	en
dc.contributor.author	Pearce, Allison	en
dc.contributor.author	Berridge, MV	en
dc.contributor.author	Larsen, L	en
dc.contributor.author	Perry, NB	en
dc.contributor.author	Sansom, CE	en
dc.contributor.author	Godfrey, CA	en
dc.contributor.author	Hanton, LR	en
dc.contributor.author	Lu, Guo-Liang	en
dc.contributor.author	Walton, M	en
dc.contributor.author	Denny, William	en
dc.contributor.author	Webb, VL	en
dc.contributor.author	Copp, Brent	en
dc.contributor.author	Harper, Jacquie	en
dc.date.accessioned	2011-11-17T17:42:00Z	en
dc.date.issued	2008	en
dc.identifier.citation	Bioorganic & Medicinal Chemistry 16(21):9432-9442 2008	en
dc.identifier.issn	0968-0896	en
dc.identifier.uri	http://hdl.handle.net/2292/9339	en
dc.description.abstract	Sixteen new thiazine–quinoline–quinones have been synthesised, plus one bicyclic analogue. These compounds inhibited neutrophil superoxide production in vitro with IC50s as low 60 nM. Compounds with high in vitro anti-inflammatory activity were also tested in a mouse model of acute inflammation. The most active compounds inhibited both neutrophil infiltration and superoxide production at doses 2.5 μmol/kg, highlighting their potential for development as novel NSAIDs.	en
dc.language	EN	en
dc.publisher	Elsevier Ltd.	en
dc.relation.ispartofseries	Bioorganic & Medicinal Chemistry	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0968-0896/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	Thiazine-quinoline-quinones	en
dc.subject	Inflammation	en
dc.subject	Superoxide	en
dc.subject	Arthritis	en
dc.subject	Neutrophils	en
dc.subject	INFLAMMATION	en
dc.subject	MECHANISMS	en
dc.title	Synthesis and anti-inflammatory structure-activity relationships of thiazine-quinoline-quinones: inhibitors of the neutrophil respiratory burst in a model of acute gouty arthritis.	en
dc.type	Journal Article	en
dc.identifier.doi	10.1016/j.bmc.2008.09.052	en
pubs.issue	21	en
pubs.begin-page	9432	en
pubs.volume	16	en
dc.rights.holder	Copyright: Elsevier Ltd.	en
dc.identifier.pmid	18835721	en
pubs.end-page	9442	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	79527	en
pubs.org-id	Medical and Health Sciences	en
pubs.org-id	Medical Sciences	en
pubs.org-id	Auckland Cancer Research	en
pubs.org-id	Science	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2010-09-01	en
pubs.dimensions-id	18835721	en