dc.contributor.author |
Smaill, Jeffrey |
en |
dc.contributor.author |
Lee, Ho |
en |
dc.contributor.author |
Palmer, Brian |
en |
dc.contributor.author |
Thompson, Andrew |
en |
dc.contributor.author |
Squire, Christopher |
en |
dc.contributor.author |
Baker, Edward |
en |
dc.contributor.author |
Booth, RJ |
en |
dc.contributor.author |
Kraker, AJ |
en |
dc.contributor.author |
Hook, K |
en |
dc.contributor.author |
Denny, William |
en |
dc.date.accessioned |
2011-11-18T01:49:24Z |
en |
dc.date.issued |
2008 |
en |
dc.identifier.citation |
Bioorganic and Medicinal Chemistry Letters 18(3):929-933 2008 |
en |
dc.identifier.issn |
0960-894X |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/9370 |
en |
dc.description.abstract |
Pyrrolo[3,4-c]carbazoles bearing solubilising basic side chains at the 8-position retain potent Wee1 and Chk1 inhibitory properties in isolated enzyme assays, and evidence of G2/M checkpoint abrogation in several cellular assays. Co-crystal structure studies confirm that the primary binding to the Wee1 enzyme is as described previously, with the C-8 side chains residing in an area of bulk tolerance. |
en |
dc.language |
EN |
en |
dc.publisher |
Elsevier Ltd. |
en |
dc.relation.ispartofseries |
Bioorganic & Medicinal Chemistry Letters |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from
http://www.sherpa.ac.uk/romeo/issn/0960-894X/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
pyrrolocarbazole |
en |
dc.subject |
G2/M checkpoint abrogation |
en |
dc.subject |
Weel kinase inhibitor |
en |
dc.subject |
Chk1 kinase inhibitor |
en |
dc.subject |
checkpoint inhibitor |
en |
dc.subject |
CARCINOMA |
en |
dc.title |
Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.bmcl.2007.12.046 |
en |
pubs.issue |
3 |
en |
pubs.begin-page |
929 |
en |
pubs.volume |
18 |
en |
dc.rights.holder |
Copyright: Elsevier Ltd. |
en |
dc.identifier.pmid |
18191399 |
en |
pubs.end-page |
933 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
98101 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Auckland Cancer Research |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Biological Sciences |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
18191399 |
en |