dc.contributor.author |
Mukherjee, S |
en |
dc.contributor.author |
James, Joanna |
en |
dc.contributor.author |
Thilaganathan, B |
en |
dc.contributor.author |
Whitley, GS |
en |
dc.contributor.author |
Michael, AE |
en |
dc.contributor.author |
Cartwright, JE |
en |
dc.coverage.spatial |
England |
en |
dc.date.accessioned |
2011-11-18T01:54:20Z |
en |
dc.date.issued |
2011-09 |
en |
dc.identifier.citation |
Placenta 32(9):687-693 Sep 2011 |
en |
dc.identifier.issn |
0143-4004 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/9371 |
en |
dc.description.abstract |
The local actions of glucocorticoids in the placenta can be modulated by 11β-hydroxysteroid dehydrogenase (11βHSD) enzymes, which catalyse inter-conversion of cortisol with its inert metabolite, cortisone, and are known to be expressed in the term placenta and decidua. However, the expression and activity of these enzymes have not been well characterised in the first trimester placenta. The aim of this study was to compare 11βHSD2 expression and activity in first trimester placental tissue from pregnancies at either relatively low or high risk of developing pre-eclampsia as determined by Doppler ultrasound. |
en |
dc.language |
eng |
en |
dc.publisher |
Elsevier Ltd. |
en |
dc.relation.ispartofseries |
Placenta |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from
http://www.sherpa.ac.uk/romeo/issn/0143-4004/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
Glucocorticoid |
en |
dc.subject |
11 beta HSD |
en |
dc.subject |
Pre-eclampsia |
en |
dc.subject |
Placenta |
en |
dc.subject |
11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2 |
en |
dc.subject |
UTERINE ARTERY DOPPLER |
en |
dc.subject |
TROPHOBLAST DIFFERENTIATION |
en |
dc.subject |
HYPERTENSIVE DISORDERS |
en |
dc.subject |
15-HYDROXYPROSTAGLANDIN DEHYDROGENASE |
en |
dc.subject |
EXPRESSION |
en |
dc.subject |
HYPOXIA |
en |
dc.subject |
OXYGEN |
en |
dc.subject |
CELLS |
en |
dc.subject |
TERM |
en |
dc.title |
Elevated glucocorticoid metabolism in placental tissue from first trimester pregnancies at increased risk of pre-eclampsia. |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.placenta.2011.06.014 |
en |
pubs.issue |
9 |
en |
pubs.begin-page |
687 |
en |
pubs.volume |
32 |
en |
dc.rights.holder |
Copyright: Elsevier Ltd. |
en |
dc.identifier.pmid |
21767875 |
en |
pubs.end-page |
693 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
219738 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
School of Medicine |
en |
pubs.org-id |
Obstetrics and Gynaecology |
en |
dc.identifier.eissn |
1532-3102 |
en |
dc.identifier.pii |
S0143-4004(11)00235-9 |
en |
pubs.record-created-at-source-date |
2011-11-18 |
en |
pubs.dimensions-id |
21767875 |
en |