Shear stress and spiral artery remodelling: the effects of low shear stress on trophoblast-induced endothelial cell apoptosis.

James, Joanna; Whitley, GS; Cartwright, JE

dc.contributor.author	James, Joanna	en
dc.contributor.author	Whitley, GS	en
dc.contributor.author	Cartwright, JE	en
dc.coverage.spatial	England	en
dc.date.accessioned	2011-11-18T02:01:09Z	en
dc.date.issued	2011-04-01	en
dc.identifier.citation	Cardiovascular Research 90(1):130-139 01 Apr 2011	en
dc.identifier.issn	0008-6363	en
dc.identifier.uri	http://hdl.handle.net/2292/9372	en
dc.description.abstract	In the first trimester of pregnancy, placental trophoblasts migrate along uterine spiral arteries (SA) and replace endothelial cells (EC) lining these vessels by mechanisms involving EC apoptosis. Inadequate SA remodelling has been associated with pre-eclampsia and intra-uterine growth restriction. Until 10-12 weeks of gestation, trophoblasts plug SA, preventing maternal blood flow into the intervillous space and resulting in high resistance, low shear flow in these vessels. We aimed to determine the effect of shear stress on trophoblast-induced EC apoptosis.	en
dc.language	eng	en
dc.publisher	Oxford University Press	en
dc.relation.ispartofseries	Cardiovascular Research	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0008-6363/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	Antigens, CD95	en
dc.subject	Apoptosis	en
dc.subject	Cell Communication	en
dc.subject	Cells, Cultured	en
dc.subject	Coculture Techniques	en
dc.subject	Dactinomycin	en
dc.subject	Endothelial Cells	en
dc.subject	Fas Ligand Protein	en
dc.subject	Female	en
dc.subject	Humans	en
dc.subject	Mechanotransduction, Cellular	en
dc.subject	Microscopy, Video	en
dc.subject	Nitric Oxide	en
dc.subject	Pregnancy	en
dc.subject	Pregnancy Trimester, First	en
dc.subject	Stress, Mechanical	en
dc.subject	Time Factors	en
dc.subject	Trophoblasts	en
dc.subject	Tumor Necrosis Factor-alpha	en
dc.subject	Uterine Artery	en
dc.title	Shear stress and spiral artery remodelling: the effects of low shear stress on trophoblast-induced endothelial cell apoptosis.	en
dc.type	Journal Article	en
dc.identifier.doi	10.1093/cvr/cvq396	en
pubs.issue	1	en
pubs.begin-page	130	en
pubs.volume	90	en
dc.rights.holder	Copyright: The Author	en
dc.identifier.pmid	21156824	en
pubs.end-page	139	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	219733	en
pubs.org-id	Medical and Health Sciences	en
pubs.org-id	School of Medicine	en
pubs.org-id	Obstetrics and Gynaecology	en
dc.identifier.eissn	1755-3245	en
dc.identifier.pii	cvq396	en
pubs.record-created-at-source-date	2011-11-18	en
pubs.dimensions-id	21156824	en