dc.contributor.author |
Yang, SJ |
en |
dc.contributor.author |
Atwell, Graham |
en |
dc.contributor.author |
Denny, William |
en |
dc.date.accessioned |
2011-11-18T02:16:51Z |
en |
dc.date.issued |
2007 |
en |
dc.identifier.citation |
Tetrahedron 63(25):5470-5476 2007 |
en |
dc.identifier.issn |
0040-4020 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/9384 |
en |
dc.description.abstract |
Aromatic asymmetric halomesylate mustards are efficiently prepared by reaction of activated aromatic chlorides with aziridineethanol/alkali metal halides, followed by mesylation of the haloalcohol. The reaction conditions are sufficiently mild to be compatible with a range of different substituents and protecting groups, including carboxylate and phosphate esters, and have been used in an improved synthesis of the anticancer bromomesylate mustard PR-104, now in clinical trials. |
en |
dc.language |
EN |
en |
dc.publisher |
Elsevier Ltd. |
en |
dc.relation.ispartofseries |
Tetrahedron |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from
http://www.sherpa.ac.uk/romeo/issn/0040-4020/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.subject |
SELECTIVE ANTITUMOR AGENTS |
en |
dc.subject |
THERAPY |
en |
dc.subject |
NITROREDUCTASE |
en |
dc.subject |
CYTOTOXICITY |
en |
dc.title |
Synthesis of asymmetric halomesylate mustards with aziridineethanol/alkali metal halides: application to an improved synthesis of the hypoxia prodrug PR-104 |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.tet.2007.04.044 |
en |
pubs.issue |
25 |
en |
pubs.begin-page |
5470 |
en |
pubs.volume |
63 |
en |
dc.rights.holder |
Copyright: Elsevier Ltd. |
en |
pubs.end-page |
5476 |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
72716 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Auckland Cancer Research |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |