Synthesis of 3H- and 2H4-labelled versions of the hypoxia-activated pre-prodrug 2-[(2-bromoethyl)-2,4-dinitro-6-[[[2-(phosphonooxy)ethyl]amino]carbonyl anilino]ethyl methanesulfonate (PR-104).

Atwell, Graham; Denny, William

dc.contributor.author	Atwell, Graham	en
dc.contributor.author	Denny, William	en
dc.date.accessioned	2011-11-18T02:16:55Z	en
dc.date.issued	2007	en
dc.identifier.citation	Journal of Labelled Compounds & Radiopharmaceuticals 50(1):7-12 2007	en
dc.identifier.issn	0362-4803	en
dc.identifier.uri	http://hdl.handle.net/2292/9385	en
dc.description.abstract	3H- and 2H4-versions of the hypoxia-activated pre-prodrug PR-104 [2-[(2-bromoethyl)-2,4-dinitro-6-[[[2-(phosphonooxy)ethyl]amino]carbonyl]anilino]ethyl methanesulfonate], labelled in the ethylcarboxamide side chain, have been prepared, respectively, by [3H]NaBH4 reduction of a precursor late stage aldehyde, and by late stage incorporation of deuterium with 2-amino[1,1,2,2-2H4]ethanol.	en
dc.language	EN	en
dc.publisher	John Wiley & Sons, Ltd.	en
dc.relation.ispartofseries	Journal of Labelled Compounds and Radiopharmaceuticals	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0362-4803/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	dinitrobenzamide mustard	en
dc.subject	hypoxia-activated prodrug	en
dc.subject	PR-104	en
dc.subject	tritium	en
dc.subject	deuterium	en
dc.title	Synthesis of 3H- and 2H4-labelled versions of the hypoxia-activated pre-prodrug 2-[(2-bromoethyl)-2,4-dinitro-6-[[[2-(phosphonooxy)ethyl]amino]carbonyl anilino]ethyl methanesulfonate (PR-104).	en
dc.type	Journal Article	en
dc.identifier.doi	10.1002/jlcr.1147	en
pubs.issue	1	en
pubs.begin-page	7	en
pubs.volume	50	en
dc.rights.holder	Copyright: John Wiley & Sons, Ltd.	en
pubs.end-page	12	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	72712	en
pubs.org-id	Medical and Health Sciences	en
pubs.org-id	Medical Sciences	en
pubs.org-id	Auckland Cancer Research	en
pubs.org-id	Science	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2010-09-01	en