Synthesis of 3H- and 2H4-labelled versions of the hypoxia-activated pre-prodrug 2-[(2-bromoethyl)-2,4-dinitro-6-[[[2-(phosphonooxy)ethyl]amino]carbonyl anilino]ethyl methanesulfonate (PR-104).

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dc.contributor.author Atwell, Graham en
dc.contributor.author Denny, William en
dc.date.accessioned 2011-11-18T02:16:55Z en
dc.date.issued 2007 en
dc.identifier.citation Journal of Labelled Compounds & Radiopharmaceuticals 50(1):7-12 2007 en
dc.identifier.issn 0362-4803 en
dc.identifier.uri http://hdl.handle.net/2292/9385 en
dc.description.abstract 3H- and 2H4-versions of the hypoxia-activated pre-prodrug PR-104 [2-[(2-bromoethyl)-2,4-dinitro-6-[[[2-(phosphonooxy)ethyl]amino]carbonyl]anilino]ethyl methanesulfonate], labelled in the ethylcarboxamide side chain, have been prepared, respectively, by [3H]NaBH4 reduction of a precursor late stage aldehyde, and by late stage incorporation of deuterium with 2-amino[1,1,2,2-2H4]ethanol. en
dc.language EN en
dc.publisher John Wiley & Sons, Ltd. en
dc.relation.ispartofseries Journal of Labelled Compounds and Radiopharmaceuticals en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0362-4803/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject dinitrobenzamide mustard en
dc.subject hypoxia-activated prodrug en
dc.subject PR-104 en
dc.subject tritium en
dc.subject deuterium en
dc.title Synthesis of 3H- and 2H4-labelled versions of the hypoxia-activated pre-prodrug 2-[(2-bromoethyl)-2,4-dinitro-6-[[[2-(phosphonooxy)ethyl]amino]carbonyl anilino]ethyl methanesulfonate (PR-104). en
dc.type Journal Article en
dc.identifier.doi 10.1002/jlcr.1147 en
pubs.issue 1 en
pubs.begin-page 7 en
pubs.volume 50 en
dc.rights.holder Copyright: John Wiley & Sons, Ltd. en
pubs.end-page 12 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 72712 en
pubs.org-id Medical and Health Sciences en
pubs.org-id Medical Sciences en
pubs.org-id Auckland Cancer Research en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2010-09-01 en


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