Wormometry-on-a-chip: Innovative technologies for in situ analysis of small multicellular organisms.

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dc.contributor.author Wlodkowic, Donald en
dc.contributor.author Khoshmanesh, K en
dc.contributor.author Akagi, J en
dc.contributor.author Williams, David en
dc.contributor.author Cooper, JM en
dc.coverage.spatial United States en
dc.date.accessioned 2011-12-01T23:19:08Z en
dc.date.issued 2011-10 en
dc.identifier.citation Cytometry Part A 79A(10):799-813 Oct 2011 en
dc.identifier.issn 1552-4922 en
dc.identifier.uri http://hdl.handle.net/2292/9688 en
dc.description.abstract Small multicellular organisms such as nematodes, fruit flies, clawed frogs, and zebrafish are emerging models for an increasing number of biomedical and environmental studies. They offer substantial advantages over cell lines and isolated tissues, providing analysis under normal physiological milieu of the whole organism. Many bioassays performed on these alternative animal models mirror with a high level of accuracy those performed on inherently low-throughput, costly, and ethically controversial mammalian models of human disease. Analysis of small model organisms in a high-throughput and high-content manner is, however, still a challenging task not easily susceptible to laboratory automation. In this context, recent advances in photonics, electronics, as well as material sciences have facilitated the emergence of miniaturized bioanalytical systems collectively known as Lab-on-a-Chip (LOC). These technologies combine micro- and nanoscale sciences, allowing the application of laminar fluid flow at ultralow volumes in spatially confined chip-based circuitry. LOC technologies are particularly advantageous for the development of a wide array of automated functionalities. The present work outlines the development of innovative miniaturized chip-based devices for the in situ analysis of small model organisms. We also introduce a new term "wormometry" to collectively distinguish these up-and-coming chip-based technologies that go far beyond the conventional meaning of the term "cytometry." en
dc.language eng en
dc.publisher Wiley-Blackwell en
dc.relation.ispartofseries Cytometry A en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1552-4922/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Wormometry-on-a-chip: Innovative technologies for in situ analysis of small multicellular organisms. en
dc.type Journal Article en
dc.identifier.doi 10.1002/cyto.a.21070 en
pubs.issue 10 en
pubs.begin-page 799 en
pubs.volume 79A en
dc.rights.holder Copyright: 2011 International Society for Advancement of Cytometry en
dc.identifier.pmid 21548078 en
pubs.end-page 813 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 230067 en
pubs.org-id Science en
pubs.org-id Chemistry en
dc.identifier.eissn 1552-4930 en
pubs.record-created-at-source-date 2011-12-02 en
pubs.dimensions-id 21548078 en

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