HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells.

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dc.contributor.author Skommer, Joanna en
dc.contributor.author Wlodkowic, Donald en
dc.contributor.author Mättö, M en
dc.contributor.author Eray, M en
dc.contributor.author Pelkonen, J en
dc.coverage.spatial England en
dc.date.accessioned 2011-12-01T23:33:16Z en
dc.date.issued 2006-03 en
dc.identifier.citation Leukemia Research 30(3):322-331 Mar 2006 en
dc.identifier.issn 0145-2126 en
dc.identifier.uri http://hdl.handle.net/2292/9705 en
dc.description.abstract The BCL-2 overexpression is a hallmark of follicular lymphoma (FL). Since patients with FL often suffer from resistant to chemotherapy refractory disease, the development of new regimens is required. Herein, we analyze for the first time the effects of a B-cell lymphoma 2 (Bcl-2) antagonist, HA14-1, alone and in combination with antineoplastic agents commonly used against follicular lymphoma, in human FL cell lines with t(14;18). All cell lines tested were sensitive to HA14-1-induced cytotoxicity and apoptosis, as depicted by morphological changes, SYTO16/PI staining, oligonucleosomal DNA fragmentation and loss of Deltapsi(m). Moreover, HA14-1 significantly enhanced dexamethasone- and doxorubicin-mediated (in schedule independent and dependent manner, respectively), but not vincristine-mediated cytotoxicity and apoptosis. en
dc.language eng en
dc.publisher Elsevier Ltd. en
dc.relation.ispartofseries Leukemia Research en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0145-2126/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Antineoplastic Agents en
dc.subject Benzopyrans en
dc.subject Cell Line, Tumor en
dc.subject DNA Fragmentation en
dc.subject Dexamethasone en
dc.subject Dose-Response Relationship, Drug en
dc.subject Doxorubicin en
dc.subject Drug Evaluation, Preclinical en
dc.subject Drug Synergism en
dc.subject Humans en
dc.subject Lymphoma, B-Cell en
dc.subject Lymphoma, Follicular en
dc.subject Membrane Potentials en
dc.subject Mitochondrial Membranes en
dc.subject Nitriles en
dc.subject Proto-Oncogene Proteins c-bcl-2 en
dc.subject Vincristine en
dc.title HA14-1, a small molecule Bcl-2 antagonist, induces apoptosis and modulates action of selected anticancer drugs in follicular lymphoma B cells. en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.leukres.2005.08.022 en
pubs.issue 3 en
pubs.begin-page 322 en
pubs.volume 30 en
dc.rights.holder Copyright: 2005 Elsevier Ltd. en
dc.identifier.pmid 16213584 en
pubs.end-page 331 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 230039 en
dc.identifier.pii S0145-2126(05)00334-6 en
pubs.record-created-at-source-date 2011-12-02 en
pubs.dimensions-id 16213584 en

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