Tumors on chips: Oncology meets microfluidics

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dc.contributor.author Wlodkowic, Donald en
dc.contributor.author Cooper, JM en
dc.coverage.spatial England en
dc.date.accessioned 2011-12-01T23:37:55Z en
dc.date.issued 2010 en
dc.identifier.citation Current Opinion in Chemical Biology 14(5):556-567 2010 en
dc.identifier.issn 1367-5931 en
dc.identifier.uri http://hdl.handle.net/2292/9719 en
dc.description.abstract Despite over 2 million papers published on cancer so far, malignancy still remains a puzzlingly complex disease with overall low survival rates. Expanding our knowledge of the molecular mechanisms of malignancy and of resistance to therapy is crucial in guiding the successful design of anti-cancer drugs and new point-of-care diagnostics. The up-and-coming microfluidic Lab-on-a-Chip (LOC) technology and micro-total analysis systems (μTAS) are arguably the most promising platforms to address the inherent complexity of cellular systems with massive experimental parallelization and 4D analysis on a single cell level. This review discusses the emerging applications of microfluidic technologies and their advantages for cancer biology and experimental oncology. We also summarize the recent advances in miniaturized systems to study cancer cell microenvironment, cancer cytomics, and real-time (4D) pharmacological screening. Microfabricated systems, such as cell microarrays, together with on-chip label-less cytometry, and micro-sorting technologies, are all highlighted with the view of describing their potential applications in pharmacological screening, drug discovery, and clinical oncology. It is envisaged that microfluidic solutions may well represent the platform of choice for next generation in vitro cancer models. en
dc.language eng en
dc.publisher Elsevier Ltd. en
dc.relation.ispartofseries Current Opinion in Chemical Biology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1367-5931/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Animals en
dc.subject Cell Separation en
dc.subject Drug Evaluation, Preclinical en
dc.subject High-Throughput Screening Assays en
dc.subject Humans en
dc.subject Microfluidic Analytical Techniques en
dc.subject Neoplasms en
dc.subject Single-Cell Analysis en
dc.title Tumors on chips: Oncology meets microfluidics en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.cbpa.2010.08.016 en
pubs.issue 5 en
pubs.begin-page 556 en
pubs.volume 14 en
dc.rights.holder Copyright: Elsevier Ltd. en
dc.identifier.pmid 20832352 en
pubs.end-page 567 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 209948 en
dc.identifier.eissn 1879-0402 en
dc.identifier.pii S1367-5931(10)00118-3 en
pubs.record-created-at-source-date 2011-12-02 en
pubs.dimensions-id 20832352 en

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