Microfluidics: new vistas for systems biology and high-throughput chemogenomics

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dc.contributor.author Wlodkowic, Donald en
dc.coverage.spatial Wellington, New Zealand en
dc.date.accessioned 2011-12-02T01:15:44Z en
dc.date.issued 2010 en
dc.identifier.citation 1st New Zealand-Taiwan Symposium on Bio-nanotechnologies, Wellington, New Zealand. 2010 en
dc.identifier.uri http://hdl.handle.net/2292/9751 en
dc.description.abstract Functional cytomics is slowly becoming an omnipotent part of the post-genomic drug discovery pipelines. The last decade, in particular, has brought many innovations to the field of cytomics and cytometry. Although, it is widely recognized in the drug discovery arena that the validation of therapeutic targets revealed by proteomic and genetic screens requires 4D functional cell-based assays, their widespread clinical applications are still underdeveloped. In this context, microfluidic technologies provide important technological advances that allows for fundamentally new capabilities in the spatiotemporal control of molecules and cells. The application of laminar fluid flow under low Reynolds numbers provides an appealing analytical avenue for a rapid delivery of reagents with unprecedented accuracy and real-time control. The confining dimensions of the microfluidic structures facilitate precise positioning of cells and sequential delivery of drugs and/or functional probes to the distinct cell microenvironment. Pioneering Lab-on-a-Chip (LOC) devices allow for a lucid integration of multiparameter data, obtained from functional cell-based assays, as well as from proteomic and genetic screening. As only low cell numbers and operational reagent volumes are required, high-throughput integrated cytomics on a single cell level finally appears within the reach of clinical diagnostics and drug screening routines. Lab-on-a-Chip microfluidic technologies provide therefore new opportunities for the development of content-rich personalized clinical diagnostics and cost effective drug discovery. It is largely anticipated that advances in microfluidic technologies should aid in tailoring of investigational therapies and support the current computational efforts in the systems biology. en
dc.relation.ispartof 1st New Zealand-Taiwan Symposium on Bio-nanotechnologies en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Microfluidics: new vistas for systems biology and high-throughput chemogenomics en
dc.type Presentation en
dc.rights.holder Copyright: the author en
pubs.author-url http://www.macdiarmid.ac.nz/news/stories/NZ-T.php en
dc.rights.accessrights http://purl.org/eprint/accessRights/OpenAccess en
pubs.subtype Conference Oral Presentation en
pubs.elements-id 249896 en
pubs.record-created-at-source-date 2011-12-02 en


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