Abstract:
Transdermal oestrogen may be safer than oral oestrogen The results of randomised studies have been fairly consistent in finding an increased risk of venous thromboembolism with oral hormone replacement therapy. The accompanying systematic review by Canonico and colleagues finds similar results.1 The review combined data from both randomised and observational studies and found that the risk of venous thromboembolism doubled with oral hormone replacement therapy compared with placebo (pooled odds ratio 2.4, 95% confidence interval 1.9 to 3.0).
