The TB Structural Genomics Consortium: A decade of progress

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dc.contributor.author Chim, N en
dc.contributor.author Habel, JE en
dc.contributor.author Johnston, Jodie en
dc.contributor.author Krieger, I en
dc.contributor.author Miallau, L en
dc.contributor.author Sankaranarayanan, R en
dc.contributor.author Morse, RP en
dc.contributor.author Bruning, J en
dc.contributor.author Swanson, S en
dc.contributor.author Kim, H en
dc.contributor.author Kim, CY en
dc.contributor.author Li, HY en
dc.contributor.author Bulloch, Esther en
dc.contributor.author Payne, RJ en
dc.contributor.author Manos-Turvey, A en
dc.contributor.author Hung, LW en
dc.contributor.author Baker, Edward en
dc.contributor.author Lott, Jeremy en
dc.contributor.author James, MNG en
dc.contributor.author Terwilliger, TC en
dc.contributor.author Eisenberg, DS en
dc.contributor.author Sacchettini, JC en
dc.contributor.author Goulding, CW en
dc.date.accessioned 2011-12-06T02:36:46Z en
dc.date.issued 2011-03 en
dc.identifier.citation Tuberculosis 91(2):155-172 Mar 2011 en
dc.identifier.issn 1472-9792 en
dc.identifier.uri http://hdl.handle.net/2292/9806 en
dc.description.abstract Summary The TB Structural Genomics Consortium is a worldwide organization of collaborators whose mission is the comprehensive structural determination and analyses of Mycobacterium tuberculosis proteins to ultimately aid in tuberculosis diagnosis and treatment. Congruent to the overall vision, Consortium members have additionally established an integrated facilities core to streamline M. tuberculosis structural biology and developed bioinformatics resources for data mining. This review aims to share the latest Consortium developments with the TB community, including recent structures of proteins that play significant roles within M. tuberculosis. Atomic resolution details may unravel mechanistic insights and reveal unique and novel protein features, as well as important protein–protein and protein–ligand interactions, which ultimately lead to a better understanding of M. tuberculosis biology and may be exploited for rational, structure-based therapeutics design. en
dc.language EN en
dc.publisher Elsevier Ltd. en
dc.relation.ispartofseries Tuberculosis en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1472-9792/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.subject Mycobacterium tuberculosis en
dc.subject Protein structure en
dc.subject X-ray crystallography en
dc.subject Structural genomics en
dc.subject Drug discovery en
dc.subject HEME-DEGRADING ENZYMES en
dc.subject MYCOBACTERIUM-TUBERCULOSIS UREASE en
dc.subject PROTEIN-PROTEIN INTERACTIONS en
dc.subject PARA-AMINOBENZOATE SYNTHESIS en
dc.subject SMALL-MOLECULE INHIBITORS en
dc.subject DISULFIDE BOND FORMATION en
dc.subject TOXIN-ANTITOXIN SYSTEMS en
dc.subject ESCHERICHIA-COLI en
dc.subject STAPHYLOCOCCUS-AUREUS en
dc.subject AMINODEOXYCHORISMATE LYASE en
dc.title The TB Structural Genomics Consortium: A decade of progress en
dc.type Journal Article en
dc.identifier.doi 10.1016/j.tube.2010.11.009 en
pubs.issue 2 en
pubs.begin-page 155 en
pubs.volume 91 en
dc.rights.holder Copyright: Elsevier Ltd. en
dc.identifier.pmid 21247804 en
pubs.end-page 172 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Review en
pubs.elements-id 204963 en
pubs.org-id Science en
pubs.org-id Biological Sciences en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
pubs.record-created-at-source-date 2011-12-06 en
pubs.dimensions-id 21247804 en


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