dc.contributor.author |
Gordon, Renee |
en |
dc.contributor.author |
McGregor, Ailsa |
en |
dc.contributor.author |
Connor, Bronwen |
en |
dc.date.accessioned |
2011-12-08T00:25:32Z |
en |
dc.date.issued |
2009 |
en |
dc.identifier.citation |
Molecular and Cellular Neuroscience 41(2):219-232 2009 |
en |
dc.identifier.issn |
1044-7431 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/9874 |
en |
dc.description.abstract |
In this study we demonstrate the chemokines MCP-1, MIP-1alpha and GRO-alpha play a role in directing adult subventricular zone (SVZ)-derived progenitor cell migration following striatal cell death. MCP-1, MIP-1alpha and GRO-alpha were significantly upregulated in the striatum 2-3 days following QA-induced lesioning, correlating with maximum SVZ-derived progenitor cell recruitment into the lesioned striatum. We established that SVZ-derived progenitor cells express receptors for each chemokine, and demonstrated MCP-1, MIP-1alpha and GRO-alpha to be potent chemoattractants for SVZ-derived progenitor cells in vitro. Immunofluorescence revealed MCP-1, MIP-1alpha and GRO-alpha are predominantly expressed in the striatum by NG2-positive cells that appear to infiltrate from the bloodstream 6 h following QA lesioning. These results indicate that upregulation of MCP-1, MIP-1alpha and GRO-alpha following striatal cell death leads to chemoattraction of SVZ-derived progenitor cells into the damaged striatum and raises a potential role for blood-derived cells in directing the recruitment of SVZ-derived progenitors following brain injury. |
en |
dc.publisher |
Elsevier Inc. |
en |
dc.relation.ispartofseries |
Molecular and Cellular Neuroscience |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from
http://www.sherpa.ac.uk/romeo/issn/1044-7431/ |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Chemokines direct neural progenitor cell migration following striatal cell loss |
en |
dc.type |
Journal Article |
en |
dc.identifier.doi |
10.1016/j.mcn.2009.03.001 |
en |
pubs.issue |
2 |
en |
pubs.begin-page |
219 |
en |
pubs.volume |
41 |
en |
dc.rights.holder |
Copyright: 2009 Elsevier Inc. |
en |
dc.identifier.pmid |
19332124 |
en |
pubs.end-page |
232 |
en |
pubs.publication-status |
Published |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Article |
en |
pubs.elements-id |
88277 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Pharmacology |
en |
pubs.record-created-at-source-date |
2010-09-01 |
en |
pubs.dimensions-id |
19332124 |
en |