High-resolution spatial analysis of slow wave initiation and conduction in porcine gastric dysrhythmia

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dc.contributor.author O'Grady, Gregory en
dc.contributor.author Egbuji, JU en
dc.contributor.author Du, P en
dc.contributor.author Lammers, WJEP en
dc.contributor.author Cheng, Leo en
dc.contributor.author Windsor, John en
dc.contributor.author Pullan, Andrew en
dc.date.accessioned 2011-11-07T21:16:55Z en
dc.date.accessioned 2011-12-12T20:59:27Z en
dc.date.issued 2011 en
dc.identifier.citation Neurogastroenterology and Motility 23(9):e345-e355 2011 en
dc.identifier.issn 1350-1925 en
dc.identifier.uri http://hdl.handle.net/2292/9987 en
dc.description.abstract Background  The significance of gastric dysrhythmias remains uncertain. Progress requires a better understanding of dysrhythmic behaviors, including the slow wave patterns that accompany or promote them. The aim of this study was to use high-resolution spatiotemporal mapping to characterize and quantify the initiation and conduction of porcine gastric dysrhythmias. Methods  High-resolution mapping was performed on healthy fasted weaner pigs under general anesthesia. Recordings were made from the gastric serosa using flexible arrays (160–192 electrodes; 7.6 mm spacing). Dysrhythmias were observed to occur in 14 of 97 individual recordings (from 8 of 16 pigs), and these events were characterized, quantified and classified using isochronal mapping and animation. Key Results  All observed dysrhythmias originated in the corpus and fundus. The range of dysrhythmias included incomplete conduction block (n = 3 pigs; 3.9 ± 0.5 cpm; normal range: 3.2 ± 0.2 cpm) complete conduction block (n = 3; 3.7 ± 0.4 cpm), escape rhythm (n = 5; 2.0 ± 0.3 cpm), competing ectopic pacemakers (n = 5, 3.7 ± 0.1 cpm) and functional re-entry (n = 3, 4.1 ± 0.4 cpm). Incomplete conduction block was observed to self-perpetuate due to retrograde propagation of wave fragments. Functional re-entry occurred in the corpus around a line of unidirectional block. ‘Double potentials’ were observed in electrograms at sites of re-entry and at wave collisions. Conclusions & Inferences  Intraoperative multi-electrode mapping of fasted weaner healthy pigs detected dysrhythmias in 15% of recordings (from 50% of animals), including patterns not previously reported. The techniques and findings described here offer new opportunities to understand the nature of human gastric dysrhythmias. en
dc.publisher BLACKWELL PUBLISHING en
dc.relation.ispartofseries Neurogastroenterology and Motility en
dc.relation.replaces http://hdl.handle.net/2292/8793 en
dc.relation.replaces 2292/8793 en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/1350-1925/ en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title High-resolution spatial analysis of slow wave initiation and conduction in porcine gastric dysrhythmia en
dc.type Journal Article en
dc.identifier.doi 10.1111/j.1365-2982.2011.01739.x en
pubs.issue 9 en
pubs.begin-page e345 en
pubs.volume 23 en
dc.rights.holder Copyright: BLACKWELL PUBLISHING en
dc.identifier.pmid 21714831 en
pubs.end-page e355 en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.subtype Article en
pubs.elements-id 259872 en
pubs.org-id Bioengineering Institute en
pubs.org-id ABI Associates en
pubs.org-id Medical and Health Sciences en
pubs.org-id School of Medicine en
pubs.org-id Surgery Department en
pubs.org-id Science en
pubs.org-id Science Research en
pubs.org-id Maurice Wilkins Centre (2010-2014) en
dc.identifier.eissn 1365-2982 en
pubs.record-created-at-source-date 2011-11-08 en
pubs.dimensions-id 21714831 en


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