Robson, JinnyAram, ParhamNash, MartynBradley, ChristopherHayward, MartinPaterson, David JTaggart, PeterClayton, Richard HKadirkamanathan, Visakan2018-10-172018-06Annals of biomedical engineering 46(6):864-876 Jun 20180090-6964https://hdl.handle.net/2292/42383In this paper, we present a novel approach to quantify the spatio-temporal organization of electrical activation during human ventricular fibrillation (VF). We propose three different methods based on correlation analysis, graph theoretical measures and hierarchical clustering. Using the proposed approach, we quantified the level of spatio-temporal organization during three episodes of VF in ten patients, recorded using multi-electrode epicardial recordings with 30 s coronary perfusion, 150 s global myocardial ischaemia and 30 s reflow. Our findings show a steady decline in spatio-temporal organization from the onset of VF with coronary perfusion. We observed transient increases in spatio-temporal organization during global myocardial ischaemia. However, the decline in spatio-temporal organization continued during reflow. Our results were consistent across all patients, and were consistent with the numbers of phase singularities. Our findings show that the complex spatio-temporal patterns can be studied using complex network analysis.Print-ElectronicItems in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htmhttps://creativecommons.org/licenses/by/4.0/PericardiumHumansVentricular FibrillationMyocardial IschemiaElectrophysiologic Techniques, CardiacFemaleMaleJournal Article10.1007/s10439-018-2007-9Copyright: The authors29546467http://purl.org/eprint/accessRights/OpenAccess1573-9686