Morse, James DAnderson, Brian J2025-03-092025-03-092025-02-04(2025). Paediatric Anaesthesia.1155-5645https://hdl.handle.net/2292/71606Many of the better current pharmacokinetic–pharmacodynamic (PKPD) studies are performed using population modeling. This can be a huge roadblock to bettering pharmacological understanding. Skills using such a methodology are not that common among pediatric anesthesia practitioners. It requires committing data to patterns that are not intuitively obvious. Templeton and colleagues have explored the impact of bispectral index (BIS) monitoring on sevoflurane dose by alternative methodology. Population modeling is not only a skill in which many have no expertise but it also has its own roadblocks. One that is central to its use is quantification of sevoflurane dose, the variable that Templeton and colleagues explored.Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.This is the peer reviewed version of the following article: (2025), Pharmacokinetic and Physiological Concepts Relevant for Determining Sevoflurane Dose. Pediatr Anesth, 35: 267-269. https://doi.org/10.1111/pan.15077, which has been published in final form at 10.1111/pan.15077. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htmbispectral indexbrain monitoringinhaled anestheticspharmacodynamicspharmacokineticssevoflurane3213 Paediatrics32 Biomedical and Clinical Sciences3202 Clinical Sciences1114 Paediatrics and Reproductive MedicineJournal Article10.1111/pan.15077Copyright: John Wiley & Sons Ltd39905620 (pubmed)1460-9592