Scragg, RMalihi, Zarintaj2019-03-062019http://hdl.handle.net/2292/45810Background: Many studies have been conducted on vitamin D supplementation within the past few decades. This has been in response to promising results of observational studies suggesting additional health benefits, beyond the previously suggested bone health, if desirable vitamin D levels achieved. As a result, a number of randomized controlled trials (RCTs) have given bolus doses of vitamin D to investigate the suggested health benefits. However, there is little data on the safety of long term large dose supplementation with vitamin D, particularly in the general population. Aims: This thesis aimed to investigate if there is any risk involved with long term (3-4 years) supplementation from a bolus dose of vitamin D3 in a RCT on 5110 middle-aged and older adults in Auckland, New Zealand.Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htmhttp://creativecommons.org/licenses/by-nc-nd/3.0/nz/ThesisCopyright: The authorhttp://purl.org/eprint/accessRights/OpenAccessQ111963317