Mathews, Divya MPeart, Jane MJohnson, Neil PSim, Robert GHeather, Natasha LWebster, DianneO'Sullivan, SusannahHofman, Paul LFrancomano, Davide2025-04-032025-04-032022-01(2022). International Journal of Endocrinology, 2022(1), 4532714.1687-8337https://hdl.handle.net/2292/71763<h4>Objective</h4>Hysterosalpingography (HSG) with oil-soluble contrast medium (OSCM) improves pregnancy rates in women with idiopathic infertility. However, OSCM has high iodine content and slow clearance resulting in potential iodine excess. If pregnancy occurs, this could impact fetal thyroid gland development and function. We aim to determine the effect of a preconceptional OSCM HSG on the thyroid function of the neonate. <i>Design and Patients</i>. This was a retrospective analysis of newborn TSH data for a cohort of neonates conceived within six months of an OSCM HSG in the Auckland region, New Zealand, from the years 2000 to 2019. Thyroid-stimulating hormone (TSH) levels of these newborns were obtained from newborn screening, which is routinely performed for all children at 48-72 hours of life. The primary outcome was the incidence of permanent or transient congenital hypothyroidism in this cohort.<h4>Results</h4>Of 146 babies included, all had normal TSH levels with values ranging from 1 to 7 mIU/L on the whole blood analysis of a capillary heel sample using the Perkin-Elmer AutoDelfia assay. Conception during the first 3 cycles following an OSCM HSG was 76%; however, TSH levels in this group were not higher than those conceived in later cycles.<h4>Conclusion</h4>Preconceptional OSCM HSG did not increase the risk of congenital hypothyroidism in the New Zealand scenario.Electronic-eCollectionItems in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm3213 Paediatrics3215 Reproductive Medicine32 Biomedical and Clinical SciencesPerinatal Period - Conditions Originating in Perinatal PeriodRare DiseasesPediatricClinical ResearchNeurologicalReproductive health and childbirthMetabolic and endocrineScience & TechnologyLife Sciences & BiomedicineEndocrinology & MetabolismCONGENITAL HYPOTHYROIDISMNEW-ZEALANDTHYROID-FUNCTIONURINARY IODINETRANSIENT HYPOTHYROIDISMNEONATES BORNLIPIODOLENDOMETRIOSISAMIODARONEMOTHERS1114 Paediatrics and Reproductive Medicine1117 Public Health and Health Services3202 Clinical sciencesJournal Article10.1155/2022/4532714Copyright: The authors35242184 (pubmed)1687-8345Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/