Wijker Naomi EVidmar SuzannaGrimwood KeithSly Peter DByrnes Catherine ACarlin John BCooper Peter JRobertson Colin FMassie R JohnKemner van de Corput Mariette PCCheney JoyceTiddens Harm AWMWainwright Claire EAustralasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) and Follow-up of the ACFBAL (CF-FAB) study groupsfollowing investigators constitute the ACFBAL Study Investigators Group:following investigators constitute the CF FAB Study Investigators Group:Additional contributions: We are indebted to all current and former clinical and research staff from Queensland Children's Hospital, Brisbane:2020-11-112020-11-112020-4-30903-1936https://hdl.handle.net/2292/53521Little is known about early predictors of later cystic fibrosis (CF) structural lung disease. This study examined early predictors of progressive structural lung abnormalities in children who completed the Australasian CF Bronchoalveolar Lavage (ACFBAL) clinical trial at age 5-years and participated in an observational follow-up study (CF-FAB).Eight Australian and New Zealand CF centres participated in CF-FAB and provided follow-up chest computed-tomography (CT) scans for children who had completed the ACFBAL study with baseline scans at age 5-years. CT scans were annotated using PRAGMA-CF scoring. Ordinal regression analysis and linear regression were used to investigate associations between PRAGMA-CF (Perth-Rotterdam Annotated Grid Morphometric Analysis for CF) outcomes at follow-up and variables measured during the ACFBAL study.99 out of 157 ACFBAL children (mean±sd age 13±1.5 years) participated in the CF-FAB study. The probability of bronchiectasis at follow-up increased with airway disease severity on the baseline CT scan. In multiple regression (retaining factors at p<0.05) the extent of bronchiectasis at follow-up was associated with baseline atelectasis (OR 7.2, 95% CI 2.4-22; p≤ 0.001), bronchoalveolar lavage (BAL) log2 interleukin (IL)-8 (OR 1.2, 95% CI 1.05-1.5; p=0.010) and body mass index z-score (OR 0.49, 95% CI 0.24-1.00; p=0.05) at age 5 years. Percentage trapped air at follow-up was associated with BAL log2 IL-8 (coefficient 1.3, 95% CI 0.57-2.1; p<0.001) at age 5 years.The extent of airway disease, atelectasis, airway inflammation and poor nutritional status in early childhood are risk factors for progressive structural lung disease in adolescence.Electronic-PrintItems in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htmAustralasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) and Follow-up of the ACFBAL (CF-FAB) study groupsfollowing investigators constitute the ACFBAL Study Investigators Group:following investigators constitute the CF FAB Study Investigators Group:Additional contributions: We are indebted to all current and former clinical and research staff from Queensland Children's Hospital, Brisbane:1102 Cardiorespiratory Medicine and Haematology1114 Paediatrics and Reproductive MedicineClinicalClinical Medicine and SciencePreventionLungRare DiseasesCystic FibrosisPediatric Research InitiativeClinical ResearchPediatricCongenital DisordersRespiratory2.2 Factors relating to physical environmentScience & TechnologyLife Sciences & BiomedicineRespiratory SystemYOUNG-CHILDRENINFANTSBRONCHIECTASISADOLESCENCECT11 Medical And Health SciencesJournal Article10.1183/13993003.01694-20192020-10-02Copyright: The authorhttp://purl.org/eprint/accessRights/RestrictedAccess1399-3003