Sperry, JonathanBrimble, Margaret2011-09-192008Synlett 2008(12):1910-1912 20080936-5214https://hdl.handle.net/2292/8053The enantioselective synthesis of the 3C protease inhibitor (-)-thysanone is described. The key step is the o-toluate anion addition to an α,β-unsaturated δ-lactone. Spectroscopic analysis of the synthetic material confirms the 1R,3S stereochemistry of the natural product.Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0936-5214/https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htmthysanonepyranonaphthoquinone3C protease3C-PROTEASE INHIBITORPYRANONAPHTHOQUINONE ANTIBIOTICSABSOLUTE-CONFIGURATIONBIOLOGICAL-ACTIVITYHAUSER ANNULATIONDEOXY ANALOGSTHYSANONESTEREOCHEMISTRYJournal Article10.1055/s-2008-1078590Copyright: Georg Thieme Verlag Stuttgart New Yorkhttp://purl.org/eprint/accessRights/RestrictedAccess