Batson, JAstin, JWNobes, CD2025-01-092025-01-092013-09(2013). Journal of Microscopy, 251(3), 232-241.0022-2720https://hdl.handle.net/2292/70996Contact inhibition of locomotion (CIL) occurs when a cell stops migrating in a particular direction upon contact with another cell. Many cancer cells show Contact inhibition of locomotion when contacting one another but display contact-unimpeded migration following collision with noncancer cells. Here we review current understanding of Contact inhibition of locomotion, from Abercrombie's historical studies of cells in tissue culture to more recent analyses of Contact inhibition of locomotion in vivo. We discuss the cellular machinery required for CIL and the molecular signals that regulate it. We focus on our recent finding that in prostate cancer cells, Contact inhibition of locomotion is regulated by a balance between EphA and EphB receptor signalling. We show that, as recently described for chick heart fibroblasts, microtubule dynamics are required for Contact inhibition of locomotion in prostate cancer cells and we propose that stabilization of microtubules could account for defective Contact inhibition of locomotion between cancer cells and noncancer cells.Print-ElectronicItems in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htmProstateCell Line, TumorMicrotubulesHumansReceptors, Eph FamilyEphrinsCell MovementContact InhibitionMaleCell migrationContact inhibition of locomotionEph receptor3101 Biochemistry and Cell Biology31 Biological SciencesProstate CancerCancerUrologic Diseases1.1 Normal biological development and functioning2.1 Biological and endogenous factorsScience & TechnologyTechnologyMicroscopyINVASIVE BEHAVIORPROSTATE-CANCERTISSUE-CULTURECELL-MIGRATIONAXON GUIDANCEIN-VITRORECEPTORSGROWTHRHO0601 Biochemistry and Cell Biology1112 Oncology and CarcinogenesisBiomedicalBasic Science0204 Condensed Matter Physics0912 Materials Engineering3406 Physical chemistry4016 Materials engineeringJournal Article10.1111/jmi.12024Copyright: The authors23495724 (pubmed)1365-2818