Agban, YosraThakur, SachinMugisho, OdunayoRupenthal, Ilva2020-02-172019-081359-6446https://hdl.handle.net/2292/50082The periocular space is a promising alternative route for the delivery of drugs to the posterior eye segment, especially when treating conditions in the outer ocular layers. In this review, we discuss the different periocular routes as well as the physiological barriers and elimination mechanisms limiting drug bioavailability at the back of the eye. We then highlight various types of depot formulations, including particulate delivery systems, semisolid formulations, and implants, used to increase the contact time with the ocular tissues. With the additional advantage of sustaining drug release, such depot formulations could enhance periocular drug delivery to the posterior eye segment.Print-ElectronicItems in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htmAnimalsHumansEye DiseasesDelayed-Action PreparationsDrug Delivery SystemsChemistry, PharmaceuticalPosterior Eye SegmentDrug LiberationJournal Article10.1016/j.drudis.2019.03.023Copyright: The authorhttp://purl.org/eprint/accessRights/RestrictedAccess1878-5832