Synthesis and evaluation of 4-substituted analogues of 5-[N,N-bis(2-chloroethyl)amino]2-nitrobenzamide as bioreductively activated prodrugs using an Escherichia coli nitroreductase

Synthesis and evaluation of 4-substituted analogues of 5-[N,N-bis(2-chloroethyl)amino]2-nitrobenzamide as bioreductively activated prodrugs using an Escherichia coli nitroreductase

Atwell, Graham ; Boyd, Maruta ; Palmer, Brian ; Anderson, Robert ; Pullen, Susan ; Wilson, William ; Denny, William
Identifier: http://hdl.handle.net/2292/14888
Issue Date: 1996
Reference: Anticancer Drug Des 11(7):553-567 Oct 1996
Rights: Copyright: Oxford University Press
Rights (URI): https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm

Abstract:

2,4-Dinitrobenzamide mustards, exemplified by the parent compound SN 23862 (2) are activated under aerobic conditions by an Escherichia coil nitroreductase enzyme (NR2) via selective reduction of the 2-nitro group, and are thus of interest as prodrug

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Related URL: http://www.ncbi.nlm.nih.gov/pubmed/8921936
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