Synthesis and evaluation of 4-substituted analogues of 5-[N,N-bis(2-chloroethyl)amino]2-nitrobenzamide as bioreductively activated prodrugs using an Escherichia coli nitroreductase

Atwell, Graham; Boyd, Maruta; Palmer, Brian; Anderson, Robert; Pullen, Susan; Wilson, William; Denny, William

dc.contributor.author	Atwell, Graham	en
dc.contributor.author	Boyd, Maruta	en
dc.contributor.author	Palmer, Brian	en
dc.contributor.author	Anderson, Robert	en
dc.contributor.author	Pullen, Susan	en
dc.contributor.author	Wilson, William	en
dc.contributor.author	Denny, William	en
dc.date.accessioned	2012-03-21T00:25:02Z	en
dc.date.issued	1996	en
dc.identifier.citation	Anticancer Drug Des 11(7):553-567 Oct 1996	en
dc.identifier.issn	0266-9536	en
dc.identifier.uri	http://hdl.handle.net/2292/14888	en
dc.description.abstract	2,4-Dinitrobenzamide mustards, exemplified by the parent compound SN 23862 (2) are activated under aerobic conditions by an Escherichia coil nitroreductase enzyme (NR2) via selective reduction of the 2-nitro group, and are thus of interest as prodrug	en
dc.relation.ispartofseries	Anti-Cancer Drug Design	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.title	Synthesis and evaluation of 4-substituted analogues of 5-[N,N-bis(2-chloroethyl)amino]2-nitrobenzamide as bioreductively activated prodrugs using an Escherichia coli nitroreductase	en
dc.type	Journal Article	en
pubs.begin-page	553	en
pubs.volume	11	en
dc.rights.holder	Copyright: Oxford University Press	en
dc.identifier.pmid	8921936	en
pubs.author-url	http://www.ncbi.nlm.nih.gov/pubmed/8921936	en
pubs.end-page	567	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	8997	en
pubs.org-id	Medical and Health Sciences	en
pubs.org-id	Medical Sciences	en
pubs.org-id	Auckland Cancer Research	en
pubs.org-id	Science	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2010-09-01	en
pubs.dimensions-id	8921936	en