Epigenetic Mechanisms

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dc.contributor.author Low, Felicia en
dc.contributor.author Tng, E en
dc.contributor.author Gluckman, Peter en
dc.contributor.editor Buonocore, G en
dc.contributor.editor Bracci, R en
dc.contributor.editor Weindling, M en
dc.date.accessioned 2015-03-05T22:07:50Z en
dc.date.issued 2012 en
dc.identifier.citation In Neonatology. Editors: Buonocore G, Bracci R, Weindling M. 26-30. Springer-Verlag Milan, Milan 2012 en
dc.identifier.isbn 978-88-470-1405-3 en
dc.identifier.uri http://hdl.handle.net/2292/24775 en
dc.description.abstract While phenotypic variation such as disease vulnerability has traditionally been viewed as being determined by the interaction between genes and the environment, it is now clear that this is over-simplistic. Developmental plasticity describes the phenomenon whereby development of the phenotype from a given genotype is influenced by developmental experiences, and phenotypic variation in turn influences how the individual interacts with its mature environment, thus affecting disease risk. It is now recognized that developmental plasticity is underpinned by epigenetic processes, which are environmentally-induced changes in the patterns and regulation of gene expression brought about by a set of modifications in DNA and DNA-associated molecules, without changes in the base sequence. Epigenetic processes are phylogenetically old, and the mechanisms involved modulate both gene dosage and the conditions under which genes are expressed. Developmental plasticity is but one of several processes which are effectuated by epigenetic mechanisms; in mammals other processes include transposon silencing, cell differentiation, X-inactivation in females and genomic imprinting. en
dc.publisher Springer-Verlag Milan en
dc.relation.ispartof Neonatology en
dc.rights Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. en
dc.rights.uri https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm en
dc.title Epigenetic Mechanisms en
dc.type Book Item en
dc.identifier.doi 10.1007/978-88-470-1405-3_5 en
pubs.begin-page 26 en
dc.rights.holder Copyright: Springer-Verlag Milan en
pubs.end-page 30 en
pubs.place-of-publication Milan en
dc.rights.accessrights http://purl.org/eprint/accessRights/RestrictedAccess en
pubs.elements-id 97707 en
pubs.number 5 en
pubs.record-created-at-source-date 2010-09-01 en

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