1-(Chloromethyl)-2,3-dihydro-1H-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

1-(Chloromethyl)-2,3-dihydro-1H-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

Flygare, JA ; Pillow, TH ; Safina, B ; Verma, V ; Wei, BQ ; Denny, William ; Giddens, Anna ; Lee, Ho ; Lu, Guo-Liang ; Miller, Christian ; Rewcastle, Gordon ; Tercel, Moana ; Bonnet, Muriel
Identifier: http://hdl.handle.net/2292/27904
Reference: Patent/Trademark number: 8,772,287 B2 (USA). Publication/Application date: 10 Jun 2013. Publication/Awarded date: 08 Jul 20
Rights (URI): https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm

Abstract:

The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.

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