1-(Chloromethyl)-2,3-dihydro-1H-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
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1-(Chloromethyl)-2,3-dihydro-1H-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
Flygare, JA
;
Pillow, TH
;
Safina, B
;
Verma, V
;
Wei, BQ
;
Denny, William
;
Giddens, Anna
;
Lee, Ho
;
Lu, Guo-Liang
;
Miller, Christian
;
Rewcastle, Gordon
;
Tercel, Moana
;
Bonnet, Muriel
Identifier:
http://hdl.handle.net/2292/27904
Reference:
Patent/Trademark number: 8,772,287 B2 (USA). Publication/Application date: 10 Jun 2013. Publication/Awarded date: 08 Jul 20
Rights (URI):
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm
Abstract:
The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
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https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2015023355
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