1-(Chloromethyl)-2,3-dihydro-1H-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment

Flygare, JA; Pillow, TH; Safina, B; Verma, V; Wei, BQ; Denny, William; Giddens, Anna; Lee, Ho; Lu, Guo-Liang; Miller, Christian; Rewcastle, Gordon; Tercel, Moana; Bonnet, Muriel

dc.contributor.author	Flygare, JA	en
dc.contributor.author	Pillow, TH	en
dc.contributor.author	Safina, B	en
dc.contributor.author	Verma, V	en
dc.contributor.author	Wei, BQ	en
dc.contributor.author	Denny, William	en
dc.contributor.author	Giddens, Anna	en
dc.contributor.author	Lee, Ho	en
dc.contributor.author	Lu, Guo-Liang	en
dc.contributor.author	Miller, Christian	en
dc.contributor.author	Rewcastle, Gordon	en
dc.contributor.author	Tercel, Moana	en
dc.contributor.author	Bonnet, Muriel	en
dc.coverage.spatial	USA	en
dc.date.accessioned	2016-01-07T04:20:00Z	en
dc.identifier.citation	Patent/Trademark number: 8,772,287 B2 (USA). Publication/Application date: 10 Jun 2013. Publication/Awarded date: 08 Jul 20	en
dc.identifier.govdoc	WO 2015/023355 A1	en
dc.identifier.uri	http://hdl.handle.net/2292/27904	en
dc.description.abstract	The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher.	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.title	1-(Chloromethyl)-2,3-dihydro-1H-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment	en
dc.type	Patent	en
pubs.author-url	https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2015023355	en
pubs.patent-status	Published Application	en
pubs.start-date	2015-02-19	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/OpenAccess	en
pubs.elements-id	510279	en
pubs.org-id	Medical and Health Sciences	en
pubs.org-id	Medical Sciences	en
pubs.org-id	Auckland Cancer Research	en
pubs.org-id	Science	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.number	PCT/US2014/042560	en
pubs.record-created-at-source-date	2015-12-02	en