dc.contributor.author |
Proft, Thomas |
en |
dc.contributor.author |
Fraser, John |
en |
dc.contributor.editor |
Ferretti, JJ |
en |
dc.contributor.editor |
Stevens, DL |
en |
dc.contributor.editor |
Fischetti, VA |
en |
dc.date.accessioned |
2016-03-02T02:17:15Z |
en |
dc.date.issued |
2016 |
en |
dc.identifier.citation |
In Streptococcus Pyogenes: Basic Biology to Clinical Manifestations, 2016, pp. 333 - 350 |
en |
dc.identifier.uri |
http://hdl.handle.net/2292/28349 |
en |
dc.description.abstract |
Superantigens (SAgs) are a family of highly potent mitogens that share the ability to trigger excessive stimulation of human and other mammalian T lymphocytes. This leads to a massive release of T cell mediators and pro-inflammatory cytokines contributing to diseases such as toxic shock syndrome. In contrast to conventional peptides, SAgs bind as unprocessed molecules to major histocompatibility (MHC) class II molecules outside the peptide-binding groove and sequentially to the variable β-chain of the T cell receptor (TcRVβ). Currently, eleven Streptococcus pyogenes SAgs are described in the literature. Together with the SAgs produced by Staphylococcus aureus, they build a larger family of structurally related, heat-stable exotoxins. This chapter provides a comprehensive overview of the discovery, biological function, and disease-associations of these remarkable proteins. |
en |
dc.description.uri |
http://www.ncbi.nlm.nih.gov/books/NBK333424/ |
en |
dc.publisher |
The University of Oklahoma Health Sciences Center |
en |
dc.relation.ispartof |
Streptococcus Pyogenes: Basic Biology to Clinical Manifestations |
en |
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
en |
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
en |
dc.title |
Streptococcal Superantigens: Biological properties and potential role in disease |
en |
dc.type |
Book Item |
en |
pubs.begin-page |
333 |
en |
dc.rights.holder |
Copyright:
The University of Oklahoma Health Sciences Center |
en |
pubs.author-url |
http://www.ncbi.nlm.nih.gov/books/NBK333435/ |
en |
pubs.end-page |
350 |
en |
pubs.place-of-publication |
Oklahoma, USA |
en |
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.elements-id |
522839 |
en |
pubs.org-id |
Medical and Health Sciences |
en |
pubs.org-id |
Medical Sciences |
en |
pubs.org-id |
Molecular Medicine |
en |
pubs.org-id |
Science |
en |
pubs.org-id |
Science Research |
en |
pubs.org-id |
Maurice Wilkins Centre (2010-2014) |
en |
pubs.record-created-at-source-date |
2016-02-16 |
en |