dc.contributor.author |
Shi, Dian |
|
dc.contributor.author |
Chang, Joshua W |
|
dc.contributor.author |
Choi, Jaimin |
|
dc.contributor.author |
Connor, Bronwen |
|
dc.contributor.author |
O'Carroll, Simon J |
|
dc.contributor.author |
Nicholson, Louise FB |
|
dc.contributor.author |
Kim, Joo Hyun |
|
dc.coverage.spatial |
United States |
|
dc.date.accessioned |
2021-11-11T22:42:52Z |
|
dc.date.available |
2021-11-11T22:42:52Z |
|
dc.date.issued |
2018-6 |
|
dc.identifier.issn |
0306-4522 |
|
dc.identifier.uri |
https://hdl.handle.net/2292/57405 |
|
dc.description.abstract |
Receptor for advanced glycation end products (RAGE) is a multi-ligand receptor involved in the pathology of several progressive neurodegenerative disorders including Huntington's disease (HD). We previously showed that the expression of RAGE and its colocalization with ligands were increased in the striatum of HD patients, increasing with grade severity, and that the pattern of RAGE expression coincided with the medio-lateral pattern of neurodegeneration. However, the exact role of RAGE in HD remains elusive. In order to address the necessity for a direct functional study, we aimed to characterize the pattern of RAGE expression in the transgenic rat model of HD (tgHD rats). Our results showed that RAGE expression was expanded laterally in tgHD rat caudate-putamen (CPu) compared to wildtype littermates, but the expression was unchanged by disease severity. The rostro-caudal location did not affect RAGE expression. RAGE was predominantly expressed in the medium spiny neurons (MSN) where it colocalized most extensively with N-carboxymethyllysine (CML), which largely contradicts with observations from human HD brains. Overall, the tgHD rat model only partially recapitulated the pattern in striatal RAGE expression in human brains, raising a question about its reliability as an animal model for future functional studies. |
|
dc.format.medium |
Print-Electronic |
|
dc.language |
eng |
|
dc.publisher |
Elsevier BV |
|
dc.relation.ispartofseries |
Neuroscience |
|
dc.rights |
Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. |
|
dc.rights.uri |
https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm |
|
dc.subject |
Corpus Striatum |
|
dc.subject |
Neurons |
|
dc.subject |
Animals |
|
dc.subject |
Rats |
|
dc.subject |
Huntington Disease |
|
dc.subject |
Disease Models, Animal |
|
dc.subject |
Female |
|
dc.subject |
Rats, Transgenic |
|
dc.subject |
Receptor for Advanced Glycation End Products |
|
dc.subject |
Huntington’s disease |
|
dc.subject |
N-carboxymethyllysine |
|
dc.subject |
S100B |
|
dc.subject |
receptor for advanced glycation end products |
|
dc.subject |
tgHD rats |
|
dc.subject |
Animals |
|
dc.subject |
Corpus Striatum |
|
dc.subject |
Disease Models, Animal |
|
dc.subject |
Female |
|
dc.subject |
Huntington Disease |
|
dc.subject |
Neurons |
|
dc.subject |
Rats |
|
dc.subject |
Rats, Transgenic |
|
dc.subject |
Receptor for Advanced Glycation End Products |
|
dc.subject |
Science & Technology |
|
dc.subject |
Life Sciences & Biomedicine |
|
dc.subject |
Neurosciences |
|
dc.subject |
Neurosciences & Neurology |
|
dc.subject |
receptor for advanced glycation end products |
|
dc.subject |
N-carboxymethyllysine |
|
dc.subject |
S100B |
|
dc.subject |
Huntington's disease |
|
dc.subject |
tgHD rats |
|
dc.subject |
HUNTINGTONS-DISEASE |
|
dc.subject |
MODEL |
|
dc.subject |
NEUROPATHOLOGY |
|
dc.subject |
1109 Neurosciences |
|
dc.subject |
Biomedical |
|
dc.subject |
Basic Science |
|
dc.subject |
Neurodegenerative |
|
dc.subject |
Huntington's Disease |
|
dc.subject |
Neurosciences |
|
dc.subject |
Rare Diseases |
|
dc.subject |
Brain Disorders |
|
dc.subject |
Neurological |
|
dc.subject |
2.1 Biological and endogenous factors |
|
dc.subject |
1109 Neurosciences |
|
dc.subject |
1701 Psychology |
|
dc.subject |
1702 Cognitive Sciences |
|
dc.title |
Receptor for Advanced Glycation End Products (RAGE) is Expressed Predominantly in Medium Spiny Neurons of tgHD Rat Striatum. |
|
dc.type |
Journal Article |
|
dc.identifier.doi |
10.1016/j.neuroscience.2018.03.042 |
|
pubs.begin-page |
146 |
|
pubs.volume |
380 |
|
dc.date.updated |
2021-10-15T01:28:21Z |
|
dc.rights.holder |
Copyright: The author |
en |
pubs.author-url |
https://www.ncbi.nlm.nih.gov/pubmed/29625216 |
|
pubs.end-page |
151 |
|
pubs.publication-status |
Published |
|
dc.rights.accessrights |
http://purl.org/eprint/accessRights/RestrictedAccess |
en |
pubs.subtype |
Research Support, Non-U.S. Gov't |
|
pubs.subtype |
Journal Article |
|
pubs.elements-id |
735718 |
|
dc.identifier.eissn |
1873-7544 |
|
dc.identifier.pii |
S0306-4522(18)30240-9 |
|