Chemoenzymatic Synthesis of Deoxy Analogues of the DNA Topoisomerase II Inhibitor Eleutherin and the 3C-Protease Inhibitor Thysanone

Chemoenzymatic Synthesis of Deoxy Analogues of the DNA Topoisomerase II Inhibitor Eleutherin and the 3C-Protease Inhibitor Thysanone

Bachu, P ; Sperry, Jonathan ; Brimble, Margaret
Identifier: http://hdl.handle.net/2292/8081
Issue Date: 2008
Reference: Tetrahedron 64 (21), 4827-4834, 2008
Rights: Copyright: 2008 Elsevier Ltd.
Rights (URI): https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm

Abstract:

The asymmetric synthesis of (-)-9-demethoxyeleutherin 6, (+)-9-demethoxyeleutherin 7 and (+)-7,9-deoxythysanone 8 has been achieved using a microwave assisted kinetic resolution of racemic alcohol 11 with Novozyme 435 (R) as the key step.

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DOI: 10.1016/j.tet.2008.01.112
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