Chemoenzymatic Synthesis of Deoxy Analogues of the DNA Topoisomerase II Inhibitor Eleutherin and the 3C-Protease Inhibitor Thysanone

Bachu, P; Sperry, Jonathan; Brimble, Margaret

dc.contributor.author	Bachu, P	en
dc.contributor.author	Sperry, Jonathan	en
dc.contributor.author	Brimble, Margaret	en
dc.date.accessioned	2011-09-19T01:55:21Z	en
dc.date.issued	2008	en
dc.identifier.citation	Tetrahedron 64 (21), 4827-4834, 2008	en
dc.identifier.issn	0040-4020	en
dc.identifier.uri	http://hdl.handle.net/2292/8081	en
dc.description.abstract	The asymmetric synthesis of (-)-9-demethoxyeleutherin 6, (+)-9-demethoxyeleutherin 7 and (+)-7,9-deoxythysanone 8 has been achieved using a microwave assisted kinetic resolution of racemic alcohol 11 with Novozyme 435 (R) as the key step.	en
dc.language	EN	en
dc.publisher	Elsevier Ltd.	en
dc.relation.ispartofseries	Tetrahedron	en
dc.rights	Items in ResearchSpace are protected by copyright, with all rights reserved, unless otherwise indicated. Previously published items are made available in accordance with the copyright policy of the publisher. Details obtained from http://www.sherpa.ac.uk/romeo/issn/0040-4020/	en
dc.rights.uri	https://researchspace.auckland.ac.nz/docs/uoa-docs/rights.htm	en
dc.subject	eleutherin	en
dc.subject	thysanone	en
dc.subject	topoisomerase II inhibitor	en
dc.subject	3C-protease inhibitor	en
dc.subject	Novozyme 4350 (Candida antarctica lipase)	en
dc.subject	microwave assisted lipase kinetic resolution	en
dc.subject	intramolecular cyclization	en
dc.subject	DOUBLE FUROFURAN ANNULATION	en
dc.subject	PYRANONAPHTHOQUINONE ANTIBIOTICS	en
dc.subject	ABSOLUTE-CONFIGURATION	en
dc.subject	EFFICIENT SYNTHESIS	en
dc.subject	NANAOMYCIN-A	en
dc.subject	MEDERMYCIN	en
dc.subject	NAPHTHOQUINONE	en
dc.subject	DERIVATIVES	en
dc.subject	GRISEUSIN	en
dc.subject	QUINONES	en
dc.title	Chemoenzymatic Synthesis of Deoxy Analogues of the DNA Topoisomerase II Inhibitor Eleutherin and the 3C-Protease Inhibitor Thysanone	en
dc.type	Journal Article	en
dc.identifier.doi	10.1016/j.tet.2008.01.112	en
pubs.issue	21	en
pubs.begin-page	4827	en
pubs.volume	64	en
dc.rights.holder	Copyright: 2008 Elsevier Ltd.	en
pubs.end-page	4834	en
dc.rights.accessrights	http://purl.org/eprint/accessRights/RestrictedAccess	en
pubs.subtype	Article	en
pubs.elements-id	80836	en
pubs.org-id	Science	en
pubs.org-id	Chemistry	en
pubs.org-id	Science Research	en
pubs.org-id	Maurice Wilkins Centre (2010-2014)	en
pubs.record-created-at-source-date	2010-09-01	en