Pharmacokinetic and Physiological Concepts Relevant for Determining Sevoflurane Dose

Abstract

Many of the better current pharmacokinetic–pharmacodynamic (PKPD) studies are performed using population modeling. This can be a huge roadblock to bettering pharmacological understanding. Skills using such a methodology are not that common among pediatric anesthesia practitioners. It requires committing data to patterns that are not intuitively obvious. Templeton and colleagues have explored the impact of bispectral index (BIS) monitoring on sevoflurane dose by alternative methodology. Population modeling is not only a skill in which many have no expertise but it also has its own roadblocks. One that is central to its use is quantification of sevoflurane dose, the variable that Templeton and colleagues explored.